We can find that people ask if a specific topic is "on topic", and how they can improve their question. There are of course the children sites of help center, and a small list of general rules have been cited here on Biology.SE.
However, I've noted that there are possibly more general rules that would be good to know about that apply to Biology.SE in particular. For example, I was advised that starting with a mathematical idea and asking where it might be applied in biology will not make for a well-formed question. One might rightly point out that the more fundamental problem with my question was that it was too broad. The inverse problem I find is figuring out ahead of time what is "too broad". Perhaps, ironically, a description of what counts as "too broad" is itself "too broad" to be fully interpreted ahead of time. I only give my previous question as an example of how it can be difficult for someone to imagine ahead of time whether their question will really be too broad.
While I'm doubtful that a perfectly comprehensive manual of all conceivable considerations is possible, I would like to know if there is a substantial guide to asking questions on Biology.SE. I understand that some may see ambiguity on what constitutes a "substantial guide", but I hope they will interpret it the best they can from the perspective of 'that which will improve the quality of questions on Biology.SE'. As vague as that is, that 'is' a goal directly compatible with 'providing high quality questions to high quality answers'.