Evolution for example, is typically one of these subjects where laymen may quickly assume they know everything there is to know. It has happen to me a few times to face OP assuming they know a whole lot about evolution while they don't. Of course, the first step in learning in often realizing what we don't understand, so it makes everything more complicated.
Religious extremists are sometimes very opinion-based when it comes to science. Of course, many creationists will fail to accept some elements of physics such as the big bang theory but I think that most of deep physics is far enough from many people everyday life and intuition that the clash is less important than with evolutionary biology. Not to forget that the modern evolutionary synthesis make a great deal at explaining the selection pressures behind behaviour which obviously deeply touches people in their own identity and may create clashes with an essentialist philosophy.